A new protein important for the fight against cancer has just been discovered. It would finally differentiate between cancer cells and healthy cells. A breakthrough that could lead to the development of new universal targeted cancer treatments, especially for cancers that do not have a dedicated treatment.
A protein called "PIP-stop", which is a kind of "switch" inside the cell, would be the key to unregulated growth that is observed with tumor cells. This is what a team of researchers has highlighted in a new study published in Nature Communications.
Researchers have found that breast cancer, leukemia, lymphoma and neuroblastoma tumor cells have too much PIP-stop protein inside the cells and that this would disrupt normal protein production function. for which the cells are provided. The excess of PIP-stop could thus divert these normal means of production so that the cell can multiply in an anarchic way.
This observation offers a new development pathway for therapeutic molecules blocking PIP-stop.
What is happening at the molecular level?
This protein is named because it impedes the interaction between proteins and lipid molecules called PIP. At the molecular level, PIP-stop is a phosphate that is inserted on the surface of the lipid binding protein PIP.
Their goal now is to develop inhibitors of PIP-stop, via intracellular kinases, to stop the progression of cancers, especially for those that are difficult to treat because we do not has no specific treatment.