Antibiotic resistance: add specific molecules to increase the effectiveness of antibiotics

These new formulas make it possible to fight against resistant forms of staphylococcus aureus.

Antibiotic resistance is one of the global health threats according to the World Health Organization. Many scientists are looking for ways to fight it. Researchers at the University of North Carolina in the United States have found that modifying an existing drug can lead to a stronger product that can attack antibiotic-resistant bacteria.

Efficiency multiplied

Staphylococcus aureus, called Staphylococcus aureus, can cause food poisoning and various serious infections. Some forms of the bacteria are particularly resistant to treatment, either because they have mutated or because they survive in parts of the body where drugs can not work. In this new research, the scientific team has added molecules, rhamnolipids, to an already existing antibiotic to enhance its effectiveness. These new molecules, produced by another type of bacteria, manage to soften the cell membrane of bacteria, to help the drug to act. Without the addition of the molecule, this type of antibiotic has little or no effect on staphylococci, whereas when incorporated into its composition, it is hundreds of times more potent.

Several resistant bacteria concerned

The modified medicine can be used to fight against bacteria that are usually very resistant: golden staphylococci able to survive in environments with little oxygen, meticillin-resistant golden staphylococci (MRSA), those resistant to tobramycin or staphylococci persistent. "There is a large number of interactions between different kinds of bacteria that could improve the effectiveness of antibiotics," says Lauren Radlinski, lead author of this study, "we want to identify them with the ultimate goal of improving the effectiveness of treatments. and slow down the growth of antimicrobial resistance. " According to the Ministry of Health, 5,543 deaths are due each year to resistant bacteria.

Video: Combating Resistance: Getting Smart About Antibiotics (April 2020).